流体机械

2014, v.42;No.501(03) 57-61

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LY0型冻干机冻干箱内压力场模拟分析
Simulating and Analyzing on the Vapor Flow in Pharmaceutical Lyophilizer

郭彦伟;李保国;郭柏松;杨春生;
GUO Yan-wei;LI Bao-guo;GUO Bai-song;YANG Chun-sheng;University of Shanghai Science and Technology;Shanghai Tofflon Science & Technology Co. Ltd.;

摘要(Abstract):

为了研究药品冻干机冻干室内水蒸气压力分布状态,使用FLUENT软件对LYO型冻干机不同结构的干燥室内水蒸气流场进行了模拟,模拟分析了干燥室中搁板面积、搁板间距、水蒸气升华量对干燥室内水蒸气压力分布的影响。模拟计算结果表明不同结构的干燥室内的水蒸气压力存在明显差异。模拟计算结果可以用于评估冻干机冻干箱内不同部位物料的干燥速率,并为确定冻干机关键结构及工艺参数提供一定的理论参考依据。
Vacuum freeze-drying technology has been widely used in the biotechnology industry,which is especially applicable to temperature-sensitive and easy-deteriorated substances that require the preservation of the original states. The purpose of this work was to study the factors that may influence the rarefied water vapor flow characteristics in the lyophilizer. This study explored the effect of distance between the shelves and the size of the shelf and the sublimation flow rate upon the performance of water vapor flow in the lyophilizer through Computational Fluid Dynamics. The simulation results can be applied to understand the lyophilization process and to determine the lyophilizer key structure and process parameters.

关键词(KeyWords): 冷冻干燥;干燥室;压力分布;FLUENT
freeze-drying;vapor flow;simulation;fluent

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基金项目(Foundation): 上海市联盟计划项目(LM201364);; 上海市农业成果转化项目(113919N0400);; 上海市教委科研创新重点资助项目

作者(Author): 郭彦伟;李保国;郭柏松;杨春生;
GUO Yan-wei;LI Bao-guo;GUO Bai-song;YANG Chun-sheng;University of Shanghai Science and Technology;Shanghai Tofflon Science & Technology Co. Ltd.;

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